Endocrine Abstracts

IntroductionSARS-CoV2 infection can worsen glycemic control regardless of history of Diabetes mellitus (DM) and may precipitate new-onset diabetes (NOD). DM is also a risk factor for a greater severity of COVID-19. At-admission hyperglycemia (AH) is a known predictor of critical illness in other diseases.AimsAssess the impact of AH, regardless of the presence of DM, on the severity of COVID-19 inpatients....

Introduction: The bidirectional relationship of risk between breast cancer (BC) and thyroid cancer (TC) has been debated. Estrogens are proposed as agents implicated in the risk of developing TC promoting thyroid tumorigenesis. Therapies that reduce the effect of estrogens on their receptors in cancer cells are widely used.Objective: To correlate the use of hormonal therapy in BC with the prevalence of TC.Material and Methods: We p...

Introduction: Some studies suggest a possible link between autoimmune thyroid disease (AITD) and thyroid cancer (TC). However, existing data is inconsistent, and no consensus exists regarding this question.Objective: The aim of this study was to analyze the association between TC and AITD, namely Hashimoto’s thyroiditis (HT) and Graves’ disease (GD).Methods: We conducted a retrospective and observational study of all pati...

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare entity. Up to 1/3 of patients with incidental bilateral adrenal nodules presents biochemical evidence of hypercortisolism responsible for obesity, diabetes mellitus (DM), arterial hypertension or dyslipidemia. Its insidious course and nonspecific signs explain the underdiagnosis of this entity.Objective: To describe the case of a patient with metabolic syndrome (MS) with h...

POEMS syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes is a rare disease that usually presents in the 6th decade. We report a case of a young male in whom the presenting manifestations were mandibular mass, adrenal insufficiency and peripheral polyneuropathy. Clinical case: A thirty-three year old man from Guinea-Bissau was admitted to our hospital with asthenia, weight loss, decreased tactile sensibility with pain ...

Introduction: Multiple Endocrine Neoplasia type 1 is an underdiagnosed autosomal dominant disorder, with inter and intrafamilial variability without a genotype-phenotype correlation.Case report: A young female (born in 1986) presented with galactorrhea and secondary amenorrhea in 2002, and investigation revealed a prolactinoma. Her brother (born in 1982) presenting gynecomastia and erectile dysfunction at age 21, was also diagnosed with prolactinoma. The...

Macroprolactin is a collective term for a heterogenous group of high molecular mass forms of prolactin with minimal bioactivity in vivo. Objective: to determine prevalence of macroprolactinemia (macroPRL) and clinical characteristics of patients with hyperprolactinemia (hyperPRL) who underwent assessment for macroPRL in Endocrinology outpatient clinic.Methods: We reviewed the medical records of 54 patients who were evaluated for macroPRL between...

Introduction: Steroid cell tumors are rare ovarian sex cord-stromal tumors with malignant potential comprising <0.1% of all ovarian tumors. A subtype called not otherwise specified (NOS) accounts for approximately one-half of all ovarian steroid cell tumors. The average age of presentation is 43 years, with androgenic clinical features in 56–77% of cases.Case report: A 21-year-old female, on liver transplantation waiting list due to Niemann&#150...

Introduction: Several studies point towards lower testosterone levels (TL) in patients with obesity and/or insulin resistance (IR).Aim: To analyze the influence of anthropometric parameters and IR on TL in obese men and weight-dependent changes after a short-term weight loss program.Methods: Data were collected from a group of male patients, aged 18 to 65, when they attended a first obesity appointment and at reassessment 6 months ...

Introduction: Medical therapy of acromegaly is indicated in patients who failed to achieve remission after surgery, with contraindication or refusal for surgical therapy or following radiotherapy in order to bridge the interval until complete remission.Objective: Evaluate the medical therapy – somatostatin analogs (SSA), dopamine agonist (DAs) and GH receptor-antagonist (Pegvisomant) – in acromegalic patients followed from 1988–2011.<p...